Optimized Multichannel tDCS vs. Conventional tDCS: A Breakthrough in Depression Treatment

Ali Salehinejad – Research Scientist, IfADo

​Dr. Mohammad Ali Salehinejad is a Senior Post-Doctoral Research Fellow at the School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), since 2024. His research focuses on cognitive neuroscience, particularly the neural mechanisms underlying theory of mind and the application of non-invasive brain stimulation techniques, such as transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), to modulate brain oscillations and treat neurological and psychiatric conditions. 

Dr. Salehinejad has contributed to studies on the induction and stabilization of gamma oscillations in the human brain, as well as the effects of intensified electrical stimulation on the prefrontal-supplementary motor network in obsessive-compulsive disorder. His work has been published in esteemed journals, including Brain Stimulation and Translational Psychiatry.

Ricardo Salvador – Brain Modeling Operations Director, Neuroelectrics

Dr. Ricardo Salvador is a distinguished biomedical engineer specializing in neuronal stimulation technologies. As a key member of Neuroelectrics in Barcelona, Spain, his expertise encompasses transcranial current stimulation (tCS), transcranial magnetic stimulation (TMS), and computational modeling. 

Dr. Salvador has significantly contributed to understanding electric field distributions in the brain during non-invasive stimulation, enhancing the precision and efficacy of neuromodulation therapies. His research is extensively cited, reflecting his influential role in advancing neurotechnology.

This webinar presents an innovative randomized controlled trial (NCT06165445) that evaluates the efficacy of optimized multichannel transcranial direct current stimulation (tDCS) compared to conventional and sham tDCS in the treatment of major depression. The study examines how each intervention affects depressive symptoms, cognitive functions, and brain connectivity in 60 patients with depression. Findings reveal the superior efficacy of the multichannel protocol, with significant symptom relief observed by the 10th session and sustained for up to 3 months post-treatment.  We will also discuss how computational brain modeling, particularly new developments in protocol optimization algorithms, was used in this study and how it can be integrated into future studies. We invite you to join us for a discussion on these results and their potential implications for the future application of tDCS in clinical practice.